diff --git a/Misc/NEWS.d/next/Build/2026-04-10-20-57-30.gh-issue-146475.SWxwGM.rst b/Misc/NEWS.d/next/Build/2026-04-10-20-57-30.gh-issue-146475.SWxwGM.rst
new file mode 100644
index 00000000000000..9c70f04c43179f
--- /dev/null
+++ b/Misc/NEWS.d/next/Build/2026-04-10-20-57-30.gh-issue-146475.SWxwGM.rst
@@ -0,0 +1 @@
+Strip CFI directives from JIT stencils to fix build failures with Apple LLVM 21.
diff --git a/Tools/jit/_optimizers.py b/Tools/jit/_optimizers.py
index ef28e0c0ddeac8..4050f089ff9be3 100644
--- a/Tools/jit/_optimizers.py
+++ b/Tools/jit/_optimizers.py
@@ -251,7 +251,14 @@ def _preprocess(self, text: str) -> str:
         # references to a local _JIT_CONTINUE label (which we will add later):
         continue_symbol = rf"\b{re.escape(self.symbol_prefix)}_JIT_CONTINUE\b"
         continue_label = f"{self.label_prefix}_JIT_CONTINUE"
-        return re.sub(continue_symbol, continue_label, text)
+        text = re.sub(continue_symbol, continue_label, text)
+        # Strip CFI directives as JIT stencils are compiled with
+        # -fno-asynchronous-unwind-tables. The optimizer can remove
+        # blocks containing .cfi_endproc while keeping the corresponding
+        # .cfi_startproc, producing unbalanced CFI frames that some
+        # assemblers reject (e.g. Apple LLVM 21):
+        text = re.sub(r"^\s*\.cfi_\w+[^\n]*$", "", text, flags=re.MULTILINE)
+        return text
 
     def _parse_instruction(self, line: str) -> Instruction:
         target = None